Conolidine is classified as an indole alkaloid, a subgroup recognized for elaborate ring constructions and diverse biological functions. Indole alkaloids, derived in the amino acid tryptophan, are prevalent in numerous plant family members, such as Apocynaceae, to which conolidine’s source

Though the opiate receptor depends on G protein coupling for sign transduction, this receptor was identified to make the most of arrestin activation for internalization from the receptor. If not, the receptor promoted no other signaling cascades (59) Modifications of conolidine have resulted in